can antibiotics cause diarrhea | Important Points

Antibiotics are a lifesaving medication prescribed to cure bacterial infections in humans and animals. They help to fight against bacterial infections that could otherwise become life-threatening. But, like all types of medication, antibiotics may have certain side effects.

One of the most common side effects associated with antibiotics is diarrhea. Antibiotic-associated diarrhea (AAD) occurs due to the negative impact of antibiotics on the gastrointestinal system. Diarrhea can cause dehydration and electrolyte imbalances, and in severe cases, it can even become fatal.

In this article, we will explore the reasons why antibiotics can cause diarrhea, the different types of antibiotics that are more likely to cause this side effect, and what you can do to prevent it.

Understanding antibiotics

Antibiotics are a type of medication that kills or inhibits the growth of bacteria. Antibiotics are prescribed to fight bacterial infections such as urinary tract infections, skin infections, respiratory infections, and ear infections. Antibiotics work by killing the bacteria or preventing its multiplication, thus slowing down the progression of the infection.

When you take an antibiotic, it not only targets the harmful bacteria but also the good bacteria that live in your gut, such as Lactobacillus and Bifidobacterium. The good bacteria in your gut are essential for maintaining the balance of your gut flora and keeping your digestive system healthy. However, when antibiotics kill the good bacteria along with the harmful ones, it disrupts the balance of the gut microbiome, causing diarrhea.

Why do antibiotics cause diarrhea?

Antibiotics can cause diarrhea by altering the microbiome of the gut. The good bacteria in your gut help digest food, boost immunity, and produce certain vitamins, such as vitamin K and vitamin B12. When antibiotics wipe out the good bacteria, it can lead to an overgrowth of harmful bacteria, such as Clostridium difficile (C. difficile).

C. difficile is a bacteria that typically lives in the gut, but when the number of good bacteria declines, C. difficile can take over and cause diarrhea. C. difficile infections can range from mild to severe, with symptoms of diarrhea, abdominal pain, and fever.

In addition to C. difficile, antibiotics can cause diarrhea by altering the gut’s motility or innate immune system. Antibiotics can also increase water secretion in the intestines, leading to watery stools and dehydration.

Types of antibiotics that are more likely to cause diarrhea

Some antibiotics have a higher likelihood of causing diarrhea than others. The following are a few classes of antibiotics that are typically associated with causing diarrhea:

1. Broad-spectrum antibiotics – Broad-spectrum antibiotics such as penicillins, cephalosporins, and macrolides kill a wide range of bacteria, including the good bacteria in the gut. The loss of these good bacteria can cause diarrhea.

2. Prolonged antibiotic treatment – Prolonged antibiotic treatment can alter the microbiome of the gut, leading to a higher likelihood of diarrhea.

3. Augmentin – Augmentin is a combination antibiotic that contains amoxicillin and clavulanic acid. Augmentin can cause diarrhea due to the clavulanic acid component.

4. Fluoroquinolones – Fluoroquinolones are antibiotics that are used to treat serious infections such as respiratory infections, urinary tract infections, and bacterial prostatitis. However, these antibiotics can cause diarrhea, and in rare cases, they have been associated with severe side effects, such as tendonitis and tendon rupture.

How can you prevent antibiotic-associated diarrhea?

If you are prescribed antibiotics, there are several steps you can take to prevent AAD:

1. Take probiotics – Probiotics are beneficial bacteria that can help restore the balance of the gut microbiome. Taking probiotics, especially strains of lactobacillus, bifidobacterium, and saccharomyces, can help to prevent AAD.

2. Change your diet – Eating a healthy diet rich in fiber, such as oats, fruits, vegetables, and whole grains, can help prevent AAD by supporting a healthy gut microbiome.

3. Stay hydrated – It’s essential to keep yourself hydrated when taking antibiotics. Diarrhea can cause dehydration, electrolyte imbalances, and other complications, so it’s vital to drink plenty of fluids.

4. Take antibiotics as directed – Taking antibiotics as directed by your healthcare provider is important to reduce the risk of AAD. Completing the full course of antibiotics as directed can help to destroy the harmful bacteria causing the infection while minimizing the damage to the good bacteria in the gut.

5. Discuss your concerns with your healthcare provider – If you are concerned about the possibility of developing AAD, discuss your concerns with your healthcare provider. They can advise you on ways to prevent AAD and recommend other medications to help manage your symptoms.


Antibiotic-associated diarrhea is a common side effect of antibiotics. When antibiotics kill the good bacteria in your gut, it alters the microbiome, leading to an overgrowth of harmful bacteria that can cause diarrhea. Some antibiotics have a higher likelihood of causing diarrhea than others, such as broad-spectrum antibiotics, Augmentin, and fluoroquinolones.

However, there are ways to prevent AAD, such as taking probiotics, changing your diet, staying hydrated, taking antibiotics as directed, and discussing your concerns with your healthcare provider. By understanding the potential risks and taking the necessary precautions, you can help to avoid the risk of antibiotic-associated diarrhea and stay healthy.

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