can antibiotics cause gastritis | Important Points

Antibiotics are a class of medications used to treat bacterial infections, and they’ve been a key tool in medicine since the discovery of penicillin in 1928. However, despite their benefits, antibiotics can sometimes have unwanted side effects including gastritis—an inflammation of the stomach lining. In this article, we’ll explore whether antibiotics can cause gastritis and how to avoid this potential side effect.

What is Gastritis?

Gastritis is a condition characterized by inflammation, irritation, or erosion of the stomach lining. This condition can range in severity from a mild irritation to a more severe condition requiring medical intervention. Common symptoms of gastritis include:

– Nausea or vomiting
– Abdominal pain or discomfort
– Indigestion or heartburn
– Loss of appetite
– Hiccups
– Dark or bloody stools
– Feeling full after eating small amounts of food

There are several causes of gastritis, including:

– Bacterial infections. Helicobacter pylori (H. pylori) is a bacterium that can cause gastritis. It’s estimated that up to 50% of the world’s population may have an H. pylori infection, but not all infections lead to gastritis or other stomach problems.
– Use of certain medications. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin can irritate the lining of the stomach and cause gastritis. Other medications that may cause gastritis include corticosteroids, immunosuppressants, and potassium supplements.
– Excessive alcohol consumption. Drinking too much alcohol can damage the lining of the stomach and cause acute gastritis.
– Stress. Prolonged stress can trigger the release of a hormone called cortisol, which can increase the acid production in the stomach and cause gastritis.

Can Antibiotics Cause Gastritis?

As we mentioned earlier, antibiotics are used to treat bacterial infections, and they do not have any direct interaction with the stomach or the digestive system. However, some antibiotics can upset the balance of bacteria in the gut, which can indirectly lead to gastritis.

Antibiotics are designed to kill bacteria, but they do not selectively target the harmful bacteria that cause an infection. Instead, they kill both the good and the bad bacteria, which can disrupt the delicate microbiome in the gut—the collection of bacterial, viral, and fungal species that coexist in the intestine. Disrupting this balance can lead to an overgrowth of harmful bacteria, which can cause inflammation and disrupt the normal functioning of the digestive system.

One of the most common antibiotics associated with gastritis is a class of medications known as macrolides. Studies have shown that macrolides, such as erythromycin and clarithromycin, can alter the gut microbiome and increase the risk of developing gastritis. This is because these antibiotics can kill the beneficial bacteria in the gut, such as lactobacilli and bifidobacteria, which help to maintain a healthy digestive system and contribute to overall health.

Additionally, some antibiotics can also cause direct damage to the lining of the stomach. For example, the antibiotic tetracycline can bind to calcium in the stomach and form insoluble complexes that deposit in the lining of the stomach. These deposits can cause irritation and inflammation, which can lead to gastritis.

How to Avoid Antibiotic-Induced Gastritis?

If you need to take antibiotics to treat an infection, there are several things you can do to minimize the risk of developing gastritis:

1. Take antibiotics as prescribed: Always take antibiotics as directed by your healthcare provider. Do not take antibiotics for longer than prescribed, and do not stop taking antibiotics before completing the entire course of treatment, even if you feel better.

2. Protect your gut microbiome: Taking antibiotics can upset the balance of bacteria in your gut. To protect your gut microbiome, consider taking a probiotic supplement or eating foods that are high in probiotics, such as yogurt, kefir, sauerkraut, and kimchi.

3. Avoid NSAIDs: As we mentioned earlier, NSAIDs, such as ibuprofen and aspirin, can irritate the lining of the stomach and cause gastritis. If you need pain relief, consider taking acetaminophen instead.

4. Consider alternative treatments: In some cases, antibiotics may not be necessary to treat an infection. For example, some ear infections can be treated with watchful waiting, meaning that symptoms are monitored for a few days before treatment is started. Talk to your healthcare provider about alternative treatments if you’re concerned about the potential side effects of antibiotics.

5. Seek medical attention if symptoms worsen: If you develop symptoms of gastritis, such as abdominal pain, nausea, or vomiting, seek medical attention immediately. Your healthcare provider can help determine the cause of your symptoms and recommend appropriate treatment.


While antibiotics are an important tool in treating bacterial infections, they can sometimes have unwanted side effects, including gastritis. To minimize the risk of developing gastritis, it’s important to take antibiotics as prescribed, protect your gut microbiome, avoid NSAIDs, consider alternative treatments, and seek medical attention if symptoms worsen. By following these guidelines, you can minimize the risk of developing gastritis and help maintain a healthy digestive system.

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